28 Conference

LIPID PROFILE PATTERNIN TYPE-2 DIABETICS FROM CENTRAL INDIA

Sunil Gupta , Anjali Kapse, Diabetes Care Center, Nagpur.

OBJECT: To study the fasting lipid profile pattern in type 2 diabetics and co-relate it with dietary habits, Waist hip ratio(W.H.R.) Body mass index (BMI),  Hypertension(HT), Coronary artery disease (CAD) and pattern of hyperglycemia.

Material: 257 diabetic males and females, both between 30 to 65 yrs . of ages were studied.

Observation:-

Category

CHOL>200

LDL>130

TG>200

COMB.DYS

LDL>130&Tg>200)

 

Male(164)

Female(93)

35.36%

39.78%

29.87%

35.48%

12.19%

25.8%

32.31%

10.75%

 

MALE

h

CHOL>200

LDL>130

TG>200

COMB.DYS

CAD

55

33.3%

40.0%

24.4%

13.3%

HT

70

16.9%

19.7%

21.1%

11.3%

FBS<140

92

26.1%

25.0%

27.2%

08.7%

FBS>140

72

37.5%

29.2%

33.3%

12.5%

FEMALE

h

CHOL>200

LDL>130

TG>200

COMB.DYS

CAD

20

40.0%

40.0%

5.0%

5.0%

HT

39

30.8%

61.1%

15.4%

5.1%

FBS<140

44

38.6%

29.5%

18.2%

4.5%

FBS>140

49

51.0%

38.8%

32.6%

16.3%

 

 

 

 

 

 

 

 

 

 

Abbreviation:

TC-Total cholesterol TG-triglyceride LDL-C-Low density lipoprotein cholesterol COMB.DY-combined dyslipidemia(LDL>130&TG>200).

More than 30% of  diabetics had dyslipidemia.  Hypercholesterolemia and raised LDL-C were as frequent as hypetriglyceridemia.  11-12% of patients had combined dyslipidemia.  Patients with FBG>140mg% were found to have a higher incidence of dyslipidemia as compared to patient with   FBS<140mg%.  Higher BMI and WHR were associated with raised TC, LDL-C, TG and combined  dyslipidemia in males.  Females with higher WHR had increased TC and LDL-C.  Higher BMI did not show such relationship in females.  WHR seems to be a better marker of dyslipidemia than BMI.

56.1% of males and 58.1% of females were not consuming ghee.  Amongst females  with dyslipidemia , significantly higher TC, LDL-C & comb.dys was observed in those consuming ghee (mean 8.2gm/day).  No such correlation was seen in males.  HDL-C    was found to be normal in both groups  (41mg%+/-7.9 in male and 43.7mg%+/-9.8 in females).  27.4% of males and  21.5% of females had CAD in the study group.  Dietary fat intake was not higher than recommended in them.  Incidence of dyslipidemia was found to be higher in CAD than in HT group.

CONCLUSION:

Incidence of dyslipidemia in DM and DM with CAD is >30% in both sexes from Central India, despite having normal unsaturated fat and low saturated fat intake.  Hyperglycemia increases the incidence of dyslipidemia.  This requires further study to look for other causes of atherosclerosis.

 
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